Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord

Summary: Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. This switch prevents axons from re-entering the midline. In insects and mammals, negative regulation of Roundabout (Robo) receptors prevents premature resp...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Madhavi Gorla, Celine Santiago, Karina Chaudhari, Awo Akosua Kesewa Layman, Paula M. Oliver, Greg J. Bashaw
Format:	Article
Language:	English
Published:	Elsevier 2019-03-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124719302669