Thiazolidinedione-Conjugated Lupeol Derivatives as Potent Anticancer Agents Through a Mitochondria-Mediated Apoptotic Pathway

To improve the potential of lupeol against cancer cells, a privileged structure, thiazolidinedione, was introduced into its C-3 hydroxy group with ester, piperazine-carbamate, or ethylenediamine as a linker, and three series of thiazolidinedione-conjugated compounds (<b>6a</b>–<b>i...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Siqi Deng, Yinxu Zhao, Xiaoshan Guo, Xian Hong, Gang Li, Yuchun Wang, Qingyi Li, Ming Bu, Ming Wang
Format:	Article
Language:	English
Published:	MDPI AG 2024-10-01
Subjects:	triterpenoid lupeol thiazolidinedione hybrids antitumor apoptotic
Online Access:	https://www.mdpi.com/1420-3049/29/20/4957