Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice

Gait ataxia is one of the most common and impactful consequences of cerebellar dysfunction. Purkinje cells, the sole output neurons of the cerebellar cortex, are often involved in the underlying pathology, but their specific functions during locomotor control in health and disease remain obfuscated....

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Dick Jaarsma, Maria B. Birkisdóttir, Randy van Vossen, Demi W.G.D. Oomen, Oussama Akhiyat, Wilbert P. Vermeij, Sebastiaan K.E. Koekkoek, Chris I. De Zeeuw, Laurens W.J. Bosman
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	Cerebellar ataxia Neurodegeneration Spinocerebellar ataxia Purkinje cell Locomotion Mouse
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996124000214