Application of the Box–Behnken Design in the Development of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Extrusion

<b>Background:</b> Curcumin and hesperetin are plant polyphenols known for their poor solubility. To address this limitation, we prepared amorphous PVP K30–phosphatidylcholine dispersions via hot-melt extrusion. <b>Methods:</b> This study aimed to evaluate the effects of the...

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發表在:	Pharmaceutics
Main Authors:	Kamil Wdowiak, Lidia Tajber, Andrzej Miklaszewski, Judyta Cielecka-Piontek
格式:	Article
語言:	英语
出版:	MDPI AG 2024-12-01
主題:	curcumin hesperetin hot-melt extrusion amorphous solid dispersion solubility-enabling formulation phospholipid
在線閱讀:	https://www.mdpi.com/1999-4923/17/1/26