Regulation of γδT17 cells by Mycobacterium vaccae through interference with Notch/Jagged1 signaling pathway

The objective of this study was to investigate the effect of Mycobacterium vaccae on Jagged 1 and gamma delta T17 (γδT17) cells in asthmatic mice. An asthma mouse model was established through immunization with ovalbumin (OVA). Gamma-secretase inhibitor (DAPT) was used to block the Notch signaling p...

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Bibliographic Details

Published in:	Brazilian Journal of Medical and Biological Research
Main Authors:	Yi En Yao, Jing Hong Zhang, Xiao Ju Chen, Jian Lin Huang, Qi Xiang Sun, Wei Wei Liu, Huan Zeng, Chao Qian Li
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica
Subjects:	Asthma Mycobacterium vaccae Jagged1 receptor γδT17 Notch signaling
Online Access:	http://www.scielo.br/pdf/bjmbr/v53n11/1414-431X-bjmbr-53-11-e9551.pdf