M-Cells Contribute to the Entry of an Oral Vaccine but Are Not Essential for the Subsequent Induction of Protective Immunity against Francisella tularensis.

M-cells (microfold cells) are thought to be a primary conduit of intestinal antigen trafficking. Using an established neutralizing anti-RANKL (Receptor Activator of NF-κB Ligand) antibody treatment to transiently deplete M-cells in vivo, we sought to determine whether intestinal M-cells were require...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Aimee L Cunningham, M Neal Guentzel, Jieh-Juen Yu, Chiung-Yu Hung, Thomas G Forsthuber, Christopher S Navara, Hideo Yagita, Ifor R Williams, Karl E Klose, Tonyia D Eaves-Pyles, Bernard P Arulanandam
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Online Access:	http://europepmc.org/articles/PMC4839702?pdf=render