Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators

Abstract Background Receptor-interacting protein kinase 2 (RIPK2) is a serine/threonine kinase whose activity propagates inflammatory signaling through its association with pattern recognition receptors (PRRs) and subsequent TAK1, NF-κB, and MAPK pathway activation. After stroke, dead and dying cell...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Jonathan Larochelle, Ryland J. Tishko, Changjun Yang, Yong Ge, Leah T. Phan, Rachel E. Gunraj, Sofia M. Stansbury, Lei Liu, Mansour Mohamadzadeh, Habibeh Khoshbouei, Eduardo Candelario-Jalil
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	RIPK2 Neuroinflammation Ischemic stroke Microglia Blood–brain barrier injury
Online Access:	https://doi.org/10.1186/s12974-023-02907-6