AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR–CHK2 interaction and prostate cancer survival

We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR directly interacts with CHK2 and ionizing radiation (IR)...

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Bibliographic Details
Published in:eLife
Main Authors: Huy Q Ta, Natalia Dworak, Melissa L Ivey, Devin G Roller, Daniel Gioeli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Subjects:
prostate
CHK2
AR
androgen receptor
prostate cancer
signaling
Online Access:https://elifesciences.org/articles/51378

Internet

https://elifesciences.org/articles/51378

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