A chimeric antigen receptor tailored to integrate complementary activation signals potentiates the antitumor activity of NK cells

Abstract Background Chimeric antigen receptors (CARs) are synthetic receptors that reprogram the target specificity and functions of CAR-expressing effector cells. The design of CAR constructs typically includes an extracellular antigen-binding moiety, hinge (H), transmembrane (TM), and intracellula...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Eunbi Yi, Eunbi Lee, Hyo Jin Park, Hyeon Ho Lee, So Hyeon Yun, Hun Sik Kim
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Natural killer cells Chimeric antigen receptor Synergistic signaling DAP10 2B4
Online Access:	https://doi.org/10.1186/s13046-025-03351-5