Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning

CD117 (c-Kit) is a tyrosine kinase receptor that is overexpressed in multiple dog tumors. There is 100% homology between the juxtamembrane domain of human and canine CD117, and many cancer-causing mutations occur in this region in both species. Thus, CD117 is an important target for cancer treatment...

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Bibliographic Details

Published in:	Antibodies
Main Authors:	Mohamed A. Alfaleh, Neetika Arora, Michael Yeh, Christopher J. de Bakker, Christopher B. Howard, Philip Macpherson, Rachel E. Allavena, Xiaoli Chen, Linda Harkness, Stephen M. Mahler, Martina L. Jones
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Subjects:	Affinity selection cancer canine CD117 c-Kit dog immunohistochemistry membrane proteins monoclonal antibody phage display sphere culture transfection veterinary oncology whole cell panning
Online Access:	https://www.mdpi.com/2073-4468/8/1/15