Exosome‐transmitted miR‐769‐5p confers cisplatin resistance and progression in gastric cancer by targeting CASP9 and promoting the ubiquitination degradation of p53

Abstract Background Cisplatin resistance is the main cause of poor clinical prognosis in patients with gastric cancer (GC). Yet, the exact mechanism underlying cisplatin resistance remains unclear. Recent studies have suggested that exocrine miRNAs found in the tumor microenvironment participate in...

Full description

Bibliographic Details
Published in:	Clinical and Translational Medicine
Main Authors:	Xinming Jing, Mengyan Xie, Kun Ding, Tingting Xu, Yuan Fang, Pei Ma, Yongqian Shu
Format:	Article
Language:	English
Published:	Wiley 2022-05-01
Subjects:	CASP9 cisplatin resistance gastric cancer miR‐769‐5p p53
Online Access:	https://doi.org/10.1002/ctm2.780

Similar Items

USP2 reversed cisplatin resistance through p53-mediated ferroptosis in NSCLC
by: Yanmei Gong, et al.
Published: (2025-02-01)

p53 in Proximal Tubules Mediates Chronic Kidney Problems after Cisplatin Treatment
by: Shuangshuang Fu, et al.
Published: (2022-02-01)

p53 inhibits CTR1-mediated cisplatin absorption by suppressing SP1 nuclear translocation in osteosarcoma
by: Lei Yong, et al.
Published: (2023-01-01)

miR-769-5p has diagnostic value in acute kidney injury in intensive care unit patients and mediates disease development by targeting SIRT6
by: Yanping Peng, et al.
Published: (2025-07-01)

Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate
by: Vasily A. Aleshin, et al.
Published: (2021-04-01)

PRIMA-1 inhibits Y220C p53 amyloid aggregation and synergizes with cisplatin in hepatocellular carcinoma
by: Mariana M. Paz, et al.
Published: (2023-04-01)

Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation
by: An-Yue Wu, et al.
Published: (2019-04-01)

Terphenyllin induces CASP3-dependent apoptosis and pyroptosis in A375 cells through upregulation of p53
by: Wei Wu, et al.
Published: (2024-08-01)

p53 deficiency mediates cisplatin resistance by upregulating RRM2 and crotonylation of RRM2K283 through the downregulation of SIRT7
by: Liangjie Sun, et al.
Published: (2024-06-01)

Is Autophagy Always a Barrier to Cisplatin Therapy?
by: Jingwen Xu, et al.
Published: (2022-03-01)

The Janus Face of p53-Targeting Ubiquitin Ligases
by: Qian Hao, et al.
Published: (2020-07-01)

Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells
by: Xiaomin Feng, et al.
Published: (2017-09-01)

TP53 mitigates cisplatin resistance in non-small cell lung cancer by mediating the effects of resistant cell-derived exosome mir-424-5p
by: Yan Deng, et al.
Published: (2024-03-01)

Remdesivir Modulates CASP8 and CASP9 Expression in COVID-19 Patients: Impact on Apoptotic Pathways and Immune Response
by: Sohameh Mohebbi, et al.
Published: (2025-06-01)

Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis
by: Wantao Liu, et al.
Published: (2023-06-01)

Lengua Azul
by: Jorge R. Rey, et al.
Published: (2008-09-01)

Melatonin promoted the therapeutic potential of cisplatin in a rat model of hepatocellular carcinoma: COX-2 and MDM2/p53/miR-155 modulation associated with cytoprotection and tumour regression
by: Asmaa Mohammed ShamsEldeen, et al.
Published: (2025-07-01)

p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners
by: Anamari Brdar, et al.
Published: (2025-09-01)

Aspirin inhibits tumor progression and enhances cisplatin sensitivity in epithelial ovarian cancer
by: Jianfeng Guo, et al.
Published: (2021-08-01)

Cell cycle-specific phosphorylation of p53 protein in A549 cells exposed to cisplatin and standardized air pollutants
by: Agata Niechoda, et al.
Published: (2023-08-01)

Pyrimidine Triones as Potential Activators of p53 Mutants
by: Maryam M. Jebril Fallatah, et al.
Published: (2024-08-01)

The Status of p53 Oligomeric and Aggregation States in Cancer
by: Guilherme A. P. de Oliveira, et al.
Published: (2020-04-01)

CircRNA SEC24A promotes osteoarthritis through miR-107-5p/CASP3 axis
by: Tuerxunjiang Dadihanc, et al.
Published: (2024-06-01)

MiR-98-5p plays suppressive effects on IL-1β-induced chondrocyte injury associated with osteoarthritis by targeting CASP3
by: Hang Lv, et al.
Published: (2024-04-01)

UBE2C promotes LUAD progression by ubiquitin-dependent degradation of p53 to inactivate the p53/p21 signaling pathway
by: Siyuan Huang, et al.
Published: (2024-10-01)

P53 and anti‐p53 autoantibody complex versus anti‐p53 antibody as a biomarker for gastrointestinal cancer
by: V. Hamidi Sofiani, et al.
Published: (2025-09-01)

Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes
by: Lev Zavileyskiy, et al.
Published: (2022-02-01)

Discovery of Drugs Targeting Mutant p53 and Progress in Nano-Enabled Therapeutic Strategy for p53-Mutated Cancers
by: Na Zhang, et al.
Published: (2025-05-01)

Helping Teens Answer the Question “Who Am I?”: Cognitive Development in Adolescents
by: Rosemary V. Barnett
Published: (2005-12-01)

P53 mRNA in- Situ Hybridization analysis and Immunohistochemical Expression in Lung Cancer: A Comparative Study.
by: Ban A. Abdul-Majeed
Published: (2010-10-01)

p53 in colorectal cancer: from a master player to a privileged therapy target
by: Sicheng Yan, et al.
Published: (2025-06-01)

Recent Synthetic Approaches towards Small Molecule Reactivators of p53
by: Jerson L. Silva, et al.
Published: (2020-04-01)

C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo
by: Robert L. Fine, et al.
Published: (2023-01-01)

Shenqifuzheng injection inhibits lactic acid-induced cisplatin resistance in NSCLC by affecting FBXO22/p53 axis through FOXO3
by: Wei Bo, et al.
Published: (2024-11-01)

P63 and P73 Activation in Cancers with p53 Mutation
by: Bi-He Cai, et al.
Published: (2022-06-01)

The antioxidant, anti-inflammatory, and anti-apoptotic effects of sesamin against cisplatin-induced renal and testicular toxicity in rats
by: Ahmed E. Altyar, et al.
Published: (2024-12-01)

A novel NUTM2A-AS1/miR-769–5p axis regulates LPS-evoked damage in human dental pulp cells via the TLR4/MYD88/NF-κB signaling
by: Jing Li, et al.
Published: (2025-07-01)

MDMX in Cancer: A Partner of p53 and a p53-Independent Effector
by: Lin W, et al.
Published: (2024-01-01)

Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
by: Liuqun Zhao, et al.
Published: (2025-07-01)

Regulation of Energy Metabolism: An Important Facet of P53 Function
by: Marc Gilbert, et al.
Published: (2017-06-01)