New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis

Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancrea...

Full description

Bibliographic Details

Published in:	Molecular & Cellular Oncology
Main Authors:	Jieli Shen, Daisy F. Rangel, Dat Ha, Amy S. Lee
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-11-01
Subjects:	er chaperone grp78 grp94 metaplasia mouse models pancreatic cancer
Online Access:	http://dx.doi.org/10.1080/23723556.2017.1345350