The Role of Mesenchymal Reprogramming in Malignant Clonal Evolution and Intra-Tumoral Heterogeneity in Glioblastoma

Glioblastoma (GBM) is the most common yet uniformly fatal adult brain cancer. Intra-tumoral molecular and cellular heterogeneities are major contributory factors to therapeutic refractoriness and futility in GBM. Molecular heterogeneity is represented through molecular subtype clusters whereby the p...

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Bibliographic Details

Published in:	Cells
Main Authors:	Qiong Wu, Anders E. Berglund, Robert J. Macaulay, Arnold B. Etame
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	glioblastoma intra-tumoral heterogeneity mesenchymal reprogramming clonal evolution anti-GBM therapy tumor microenvironment
Online Access:	https://www.mdpi.com/2073-4409/13/11/942