c-Jun promotes neuroblastoma cell differentiation by inhibiting APC formation via CDC16 and reduces neuroblastoma malignancy

Abstract Neuroblastoma is a pediatric embryonal malignancy characterized by impaired neuronal differentiation. Differentiation status in neuroblastoma strongly affects the clinical outcome, thus, enforcement of differentiation becomes a treatment strategy for this disease. However, the molecular mec...

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Bibliographic Details

Published in:	Biology Direct
Main Authors:	Yunyun Wang, Jingjing Huang, Zhenhua Song, Shuo Zhang, Haojie Guo, Qi Leng, Na Fang, Shaoping Ji, Jian Yang
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	c-Jun CDC16 Anaphase-promoting complex Cell differentiation Neuroblastoma
Online Access:	https://doi.org/10.1186/s13062-025-00630-1