Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients display copy number loss of MPC1 in around 78% of...

Full description

Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	Proline High grade serous ovarian cancer PYCR1 PYCR2 PYCR3 Mitochonrial pyruvate carrier
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877824000310