Grouper cGAS is a negative regulator of STING-mediated interferon response

Cyclic GMP-AMP synthase (cGAS) is one of the classical pattern recognition receptors that recognizes mainly intracytoplasmic DNA. cGAS induces type I IFN responses to the cGAS-STING signaling pathway. To investigate the roles of cGAS-STING signaling pathway in grouper, a cGAS homolog (named EccGAS)...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Luhao Zhang, Xin Zhang, Jiaming Liao, Linting Xu, Shaozhu Kang, Hong Chen, Mengshi Sun, Siting Wu, Zhuqing Xu, Shina Wei, Qiwei Qin, Jingguang Wei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	Epinephelus coioides CGAS SGIV virus replication STING
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1092824/full