Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine

Protein tyrosine phosphatases (PTPs) are critical regulators of cellular signal transduction that catalyze the hydrolytic dephosphorylation of phosphotyrosine in substrate proteins. Among several conserved features in classical PTP domains are an active-site cysteine residue that is necessary for ca...

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Bibliographic Details

Published in:	Biochemistry and Biophysics Reports
Main Authors:	Matthew T.N. Yarnall, Sean H. Kim, Samuel Korntner, Anthony C. Bishop
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Subjects:	Protein tyrosine phosphatases Backdoor cysteines SHP1 SHP2 PTP1B Protein stability
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580822001704