Molecular and transcriptional basis of bidirectional CD4+ T cell exhaustion in oropharyngeal squamous cell carcinoma

Abstract Tumor‐infiltrating CD4+ T cells orchestrate the adaptive immune response through remarkable plasticity, and the expression patterns of exhaustion‐related inhibitory receptors in these cells differ significantly from those of CD8+ T cells. Thus, a better understanding of the molecular basis...

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Bibliographic Details

Published in:	MedComm
Main Authors:	Danni Cheng, Ke Qiu, Daibo Li, Minzi Mao, Yufang Rao, Yao Song, Lan Feng, Xiuli Shao, Chuanhuan Jiang, Yan Wang, Li Li, Xuemei Chen, Sisi Wu, Haiyang Wang, Jun Liu, Haopeng Yu, Wei Zhang, Fei Chen, Yu Zhao, Jianjun Ren
Format:	Article
Language:	English
Published:	Wiley 2024-06-01
Subjects:	CD4‐positive T‐lymphocytes head and neck cancer immune checkpoint inhibitors T cell exhaustion tumor microenvironment
Online Access:	https://doi.org/10.1002/mco2.572