Leucine‐rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule‐associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism

Abstract Mutations in LRRK2 (encoding leucine‐rich repeat kinase 2 protein, LRRK2) are the most common genetic risk factors for Parkinson's disease (PD), and increased LRRK2 kinase activity was observed in sporadic PD. Therefore, inhibition of LRRK2 has been tested as a disease‐modifying therap...

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Bibliographic Details

Published in:	MedComm
Main Authors:	Kang Chen, Fei Tang, Bin Du, Zhe‐Zhou Yue, Ling‐Ling Jiao, Xu‐Long Ding, Qing‐Zhang Tuo, Jie Meng, Si‐Yu He, Lunzhi Dai, Peng Lei, Xia‐Wei Wei
Format:	Article
Language:	English
Published:	Wiley 2023-12-01
Subjects:	A53T LRRK2 MAP1B MPTP Parkinson's disease
Online Access:	https://doi.org/10.1002/mco2.429