cis–trans Isomerization of silybins A and B

Methods were developed and optimized for the preparation of the 2,3-cis- and the 10,11-cis-isomers of silybin by the Lewis acid catalyzed (BF3∙OEt2) isomerization of silybins A (1a) and B (1b) (trans-isomers). The absolute configuration of all optically pure compounds was determined by using NMR and...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Beilstein Journal of Organic Chemistry
المؤلفون الرئيسيون:	Michaela Novotná, Radek Gažák, David Biedermann, Florent Di Meo, Petr Marhol, Marek Kuzma, Lucie Bednárová, Kateřina Fuksová, Patrick Trouillas, Vladimír Křen
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Beilstein-Institut 2014-05-01
الموضوعات:	2,3-cis-silybin 10,11-cis-silybin isomerization silibinin silybin silymarin
الوصول للمادة أونلاين:	https://doi.org/10.3762/bjoc.10.105

مواد مشابهة

A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties
حسب: Valeria Romanucci, وآخرون
منشور في: (2018-12-01)

Looking beyond silybin: the importance of other silymarin flavonolignans
حسب: Michal Selc, وآخرون
منشور في: (2025-07-01)

Protective Effect of Silybin in Rats Liver Toxicity
حسب: Roxana Popescu, وآخرون
منشور في: (2023-10-01)

Phosphodiester Silybin Dimers Powerful Radical Scavengers: A Antiproliferative Activity on Different Cancer Cell Lines
حسب: Valeria Romanucci, وآخرون
منشور في: (2022-03-01)

7-<i>O</i>-tyrosyl Silybin Derivatives as a Novel Set of Anti-Prostate Cancer Compounds
حسب: Valeria Romanucci, وآخرون
منشور في: (2024-03-01)

Nanoparticle-boosted silymarin: Are we overlooking taxifolin and other key components?
حسب: Michal Selc, وآخرون
منشور في: (2025-08-01)

Silymarin and Derivatives: From Biosynthesis to Health Benefits
حسب: Dominique Delmas
منشور في: (2020-05-01)

Determination of flavonolignans of dried fruits of Silybum marianum )L.( Gaertn. collected from different areas of Iran by spectrophotometry, TLC and HPLC
حسب: T Hasanloo, وآخرون
منشور في: (2005-02-01)

Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
حسب: Peter F. Surai
منشور في: (2015-03-01)

HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies
حسب: Haneen Amawi, وآخرون
منشور في: (2017-08-01)

Silybin Cocrystals with Improved Solubility and Bioavailability
حسب: Bingqing Zhu, وآخرون
منشور في: (2025-01-01)

Development of an HPLC-MS/MS Method for the Determination of Silybin in Human Plasma, Urine and Breast Tissue
حسب: Matteo Lazzeroni, وآخرون
منشور في: (2020-06-01)

Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-Inflammatory Potential
حسب: Simona Dobiasová, وآخرون
منشور في: (2020-05-01)

Dose Effect of Milk Thistle (<i>Silybum marianum</i>) Seed Cakes on the Digestibility of Nutrients, Flavonolignans and the Individual Components of the Silymarin Complex in Horses
حسب: Hana Dockalova, وآخرون
منشور في: (2021-06-01)

Impact of Silibinin A on Bioenergetics in PC12APP<sub>sw</sub> Cells and Mitochondrial Membrane Properties in Murine Brain Mitochondria
حسب: Carsten Esselun, وآخرون
منشور في: (2021-09-01)

A Comprehensive Review on the Antibacterial, Antifungal, Antiviral, and Antiparasitic Potential of Silybin
حسب: José Lima Pereira-Filho, وآخرون
منشور في: (2024-11-01)

A systematic review of silymarin and silibinin mechanisms for attenuating cerebral ischemia-reperfusion injuries
حسب: Hossein Mardani-Nafchi, وآخرون
منشور في: (2025-07-01)

Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
حسب: Dominique Delmas, وآخرون
منشور في: (2020-04-01)

Flavonolignans inhibit the arachidonic acid pathway in blood platelets
حسب: Michal Bijak, وآخرون
منشور في: (2017-08-01)

Effects of silybin supplementation on growth performance, serum indexes and liver transcriptome of Peking ducks
حسب: Ziyue Zhang, وآخرون
منشور في: (2024-01-01)

Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid
حسب: Costas Tsioptsias, وآخرون
منشور في: (2022-09-01)

Mechanistic Insights into the Pharmacological Significance of Silymarin
حسب: Karan Wadhwa, وآخرون
منشور في: (2022-08-01)

Influence of irrigation and row spacing on the growth, seed yield and active substance of milk thistle (Silybum marianum)
حسب: G. Karimzedah, وآخرون
منشور في: (2001-09-01)

Synergistic effects of silybin and curcumin on virulence and carbapenemase genes expression in multidrug resistant Klebsiella oxytoca
حسب: Farah H. Omer, وآخرون
منشور في: (2022-10-01)

Silybin Modulates Collagen Turnover in an In Vitro Model of NASH
حسب: Beatrice Anfuso, وآخرون
منشور في: (2019-04-01)

Gut microbiome-induced metabolites promote the role of Silybin as adjunctive drug in HIV-positive immunological nonresponders
حسب: Wenli Liu, وآخرون
منشور في: (2025-12-01)

Insight into the inhibitory activity of mangiferin and Silybin against HER2 and EGFR using theoretical and experimental approaches
حسب: Jesús Eduardo Alvarado-Lozano, وآخرون
منشور في: (2025-03-01)

Combined use of hepatoprotective agents
حسب: S. V. Okovity
منشور في: (2021-06-01)

Silybin Derivatives Produced by γ-Irradiation and Their Tyrosinase Inhibitory Activities
حسب: Ah-Reum Han, وآخرون
منشور في: (2024-11-01)

Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders
حسب: Selc M, وآخرون
منشور في: (2024-10-01)

Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
حسب: Alessandro Federico, وآخرون
منشور في: (2017-01-01)

Silybin Alleviated Hepatic Injury by Regulating Redox Balance, Inflammatory Response, and Mitochondrial Function in Weaned Piglets under Paraquat-Induced Oxidative Stress
حسب: Long Cai, وآخرون
منشور في: (2024-03-01)

Silybum marianum (L.) Gaertn'den Silymarin Ekstraksiyon Koşullarının Optimizasyonu ve Miktar Tayini için HPLC Yönteminin Geliştirilmesi
حسب: Erten AKBEL, وآخرون
منشور في: (2024-03-01)

Pharmacological and Pharmacognosticl Activity of Silybum marianum
حسب: Huda Khalil Al-Bazaz, وآخرون
منشور في: (2020-09-01)

Evaluation of Silybin Nanoparticles against Liver Damage in Murine <i>Schistosomiasis mansoni</i> Infection
حسب: Daniel Figueiredo Vanzan, وآخرون
منشور في: (2024-05-01)

Cancer chemoprevention through dietary flavonoids: what’s limiting?
حسب: Haneen Amawi, وآخرون
منشور في: (2017-06-01)

Flavonolignans silybin, silychristin and 2,3-dehydrosilybin showed differential cytoprotective, antioxidant and anti-apoptotic effects on splenocytes from Balb/c mice
حسب: Zuzana Jurčacková, وآخرون
منشور في: (2025-02-01)

Silybin Meglumine Mitigates CCl<sub>4</sub>-Induced Liver Fibrosis and Bile Acid Metabolism Alterations
حسب: Xiaoxin Liu, وآخرون
منشور في: (2024-10-01)

Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2
حسب: Shi-Bing Zhang, وآخرون
منشور في: (2022-08-01)

Silybin, the Main Active Component of <i>Silybum marianum</i>, Affects Blood Coagulation: An In Vitro Pilot Study
حسب: Agnieszka Mlicka, وآخرون
منشور في: (2023-03-01)