Coordination between p21 and DDB2 in the cellular response to UV radiation.
The tumor suppressor p53 guides the cellular response to DNA damage mainly by regulating expression of target genes. The cyclin-dependent kinase inhibitor p21, which is induced by p53, can both arrest the cell cycle and inhibit apoptosis. Interestingly, p53-inducible DDB2 (damaged-DNA binding protei...
| Published in: | PLoS ONE |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Online Access: | http://europepmc.org/articles/PMC3832521?pdf=render |