Study on Pharmacokinetics and Metabolic Profiles of Novel Potential PLK-1 Inhibitors by UHPLC-MS/MS Combined with UHPLC-Q-Orbitrap/HRMS

PLK-1 (Polo-like kinase-1) plays an essential role in cytokinesis, and its aberrant expression is considered to be keenly associated with a wide range of cancers. It has been selected as an appealing target and small-molecule inhibitors have been developed and studied in clinical trials. Unfortunate...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Lin Wang, Hui Lei, Jing Lu, Wenyan Wang, Chunjiao Liu, Yunjie Wang, Yifei Yang, Jingwei Tian, Jianzhao Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	PLK-1 biological evaluation pharmacokinetic metabolic UHPLC-MS/MS UHPLC-Q-Orbitrap/HRMS
Online Access:	https://www.mdpi.com/1420-3049/28/6/2550