The NADPH Oxidase Inhibitor, Mitoapocynin, Mitigates DFP-Induced Reactive Astrogliosis in a Rat Model of Organophosphate Neurotoxicity

NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitochondrial-targeted NOX inhibitor, reduced oxidative...

Full description

Bibliographic Details

Published in:	Antioxidants
Main Authors:	Christina Meyer, Elizabeth Grego, Suraj S. Vasanthi, Nikhil S. Rao, Nyzil Massey, Claire Holtkamp, Joselyn Huss, Lucas Showman, Balaji Narasimhan, Thimmasettappa Thippeswamy
Format:	Article
Language:	English
Published:	MDPI AG 2023-11-01
Subjects:	NADPH oxidase (NOX) GP91<i><sup>phox</sup></i> oxidative stress astrogliosis DFP (diisopropyl fluorophosphate) nanoparticles
Online Access:	https://www.mdpi.com/2076-3921/12/12/2061