CCT196969 inhibits TNBC by targeting the HDAC5/RXRA/ASNS axis to down-regulate asparagine synthesis
Abstract Background Triple-negative breast cancer (TNBC) seriously threatens the health of patients, and new therapeutic targets and drugs need to be explored. Studies have shown that CCT196969 can inhibit melanoma and colorectal cancer. However, the role of CCT196969 in TNBC is unclear. Methods CCT...
| Published in: | Journal of Experimental & Clinical Cancer Research |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-025-03494-5 |