Observations on the Changing Shape of the Ice Mass and the Determination of the Sublimation End Point in Freeze-Drying: An Application for Through-Vial Impedance Spectroscopy (TVIS)

Models for ice sublimation from a freeze-drying vial rely on the assumption of a planar ice interface up to ~25% loss of ice mass (which is difficult to qualify) whereas single-vial determinations of the sublimation endpoint (by temperature sensors) are based on the point when the observed temperatu...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Pharmaceutics
المؤلفون الرئيسيون: Bhaskar Pandya, Geoff Smith, Irina Ermolina, Evgeny Polygalov
التنسيق: مقال
اللغة:الإنجليزية
منشور في: MDPI AG 2021-11-01
الموضوعات:
freeze-drying
primary drying endpoint
thermocouple
single-vial
process analytical technology
الوصول للمادة أونلاين:https://www.mdpi.com/1999-4923/13/11/1835

الانترنت

https://www.mdpi.com/1999-4923/13/11/1835

مواد مشابهة