SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease

Abstract Background Alzheimer’s Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic GABA and H2O2 are associated with memory impairment in AD and synthesized through the Monoamine Oxidase B (MAOB)-mediated multi-step degradation of putrescine. Howev...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Mridula Bhalla, Jinhyeong Joo, Daeun Kim, Jeong Im Shin, Yongmin Mason Park, Yeon Ha Ju, Uiyeol Park, Seonguk Yoo, Seung Jae Hyeon, Hyunbeom Lee, Junghee Lee, Hoon Ryu, C. Justin Lee
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Subjects:	Alzheimer’s disease Reactive astrocytes SIRT2 GABA Amyloid-beta ALDH1A1
Online Access:	https://doi.org/10.1186/s13024-024-00788-8