Hederagenin promotes SIRT6 to attenuate epidural scar formation by aggravating PRMT1 deacetylation

Aims: The formation of a postoperative epidural scar induced by epidural fibrosis is the main reason for recurrence of lumbar disc herniation after laminectomy. Hederagenin (HE) has been found to be widely present in various medicinal plants and has various pharmacological functions. This study aim...

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Bibliographic Details
Published in:Bone & Joint Research
Main Authors: Xiao-Chen Fan, Jue Wang
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-06-01
Subjects:
hederagenin
deacetylation
endoplasmic reticulum stress
epidural scar formation
sirt6
fibrosis
fibroblasts
transforming growth factor beta 1
apoptosis
western blotting
laminectomy
nuclear factor-κb
arginine
flow cytometry
lumbar disc herniation
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.146.BJR-2024-0287.R2

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.146.BJR-2024-0287.R2

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