Therapeutic evaluation of iPSC-derived CD146+ mesenchymal stem cells in ulcerative colitis: biological properties and potential mechanisms

Abstract Background Mesenchymal stem cells (MSCs) exhibit therapeutic potential for ulcerative colitis (UC) due to their immunomodulatory, homing, and tissue repair capabilities, but clinical efficacy is constrained by heterogeneity. Induced pluripotent stem cell-derived mesenchymal stem cells (iMSC...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Lv Tian, Yiming Wang, Lei Shen, Mingru Zong, Jun Fan, Yuxin Lu, Xiaochen Cheng, Li Du, Lin Zhang, Fengjun Xiao
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	CD146 iPSC-derived mesenchymal stem cells Ulcerative colitis
Online Access:	https://doi.org/10.1186/s13287-025-04695-7