Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson’s disease? A discussion of data from the culture dish to the clinic

The neurotrophic signaling of glial cell line-derived neurotrophic factor (GDNF) with its canonical receptor, the receptor tyrosine kinase RET, coupled together with the GDNF family receptor alpha 1 is important for dopaminergic neuron survival and physiology in cell culture experiments and animal m...

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Bibliographic Details

Published in:	Neural Regeneration Research
Main Authors:	James A Conway, Edgar R Kramer
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2022-01-01
Subjects:	α-synuclein; clinical trials; dopaminergic neurons; glial cell line-derived neurotrophic factor; gfrα1; gut-brain axis; nedd4; parkin; parkinson’s disease; ret
Online Access:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=7;spage=1462;epage=1467;aulast=Conway