mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons

The mechanistic target of rapamycin (mTOR) pathway plays an important role in regulating multiple cellular processes, including cell growth, autophagy, proliferation, protein synthesis, and lipid synthesis, among others. Given the central role of this pathway in multiple cellular processes, it is no...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Elizabeth D. Buttermore, Gayathri Rajaram Srinivasan, Hellen Jumo, Amanda C. Swanson, Benjamin O’Kelly, Nina R. Makhortova, Mustafa Sahin, Stelios T. Tzannis
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	mTORC1 mTORC2 iPSC-derived neurons TSC2 mTOR hyperexcitability
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1595880/full