Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro.

Obscurin is a giant muscle protein (>800 kDa) featuring multiple signalling domains, including an SH3-DH-PH domain triplet from the Trio-subfamily of guanosine nucleotide exchange factors (GEFs). While previous research suggests that these domains can activate the small GTPases RhoA and RhoQ in c...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Daniel Koch, Ay Lin Kho, Atsushi Fukuzawa, Alexander Alexandrovich, Kutti J Vanaanen, Andrew Beavil, Mark Pfuhl, Martin Rees, Mathias Gautel
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0284453&type=printable