Isoleucine gate blocks K+ conduction in C-type inactivation

Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the selectivity filter toward a non-conductive state. Rec...

Full description

Bibliographic Details

Published in:	eLife
Main Authors:	Werner Treptow, Yichen Liu, Carlos AZ Bassetto, Bernardo I Pinto, Joao Antonio Alves Nunes, Ramon Mendoza Uriarte, Christophe J Chipot, Francisco Bezanilla, Benoit Roux
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-11-01
Subjects:	ion conduction membrane free energy conformation electrophysioloby molecular dynamics
Online Access:	https://elifesciences.org/articles/97696