Severe CSF immune cell alterations in cryptococcal meningitis gradually resolve during antifungal therapy

Abstract Cryptococcal meningitis (CM) is a severe fungal disease in immunocompromised patients affecting the central nervous system (CNS). Host response and immunological alterations in the cerebrospinal fluid (CSF) after invasion of Cryptococcus neoformans to the central nervous system have been in...

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Bibliographic Details

Published in:	BMC Neurology
Main Authors:	Christine Dambietz, Michael Heming, Tobias J. Brix, Andreas Schulte-Mecklenbeck, Phil-Robin Tepasse, Catharina C. Gross, Jonel Trebicka, Heinz Wiendl, Gerd Meyer zu Hörste
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Fungal meningitis Cryptococcus neoformans HIV Antifungal therapy Intrathecal immunity Flow cytometry
Online Access:	https://doi.org/10.1186/s12883-024-03742-9