Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3+ T reg induction capacity

Abstract Background Mesenchymal stem cells (MSCs) exhibit active abilities to suppress or modulate deleterious immune responses by various molecular mechanisms. These cells are the subject of major translational efforts as cellular therapies for immune-related diseases and transplantations. Plenty o...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Yi Yu, Alejandra Vargas Valderrama, Zhongchao Han, Georges Uzan, Sina Naserian, Estelle Oberlin
Format:	Article
Language:	English
Published:	BMC 2021-02-01
Subjects:	Fetal liver Adult bone marrow Mesenchymal stem cells T cell immunomodulation Induced regulatory T cells
Online Access:	https://doi.org/10.1186/s13287-021-02176-1