Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents

IntroductionThe multi-targeted ligands (MTDL) strategy has been recognized as a promising Approach for the development of effective treatments against Alzheimer’s disease (AD), due to the presence of multiple pathological mechanisms in AD. In this study, a series of bis(7)-harmine derivatives were d...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Hongtao Du, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	Alzheimer’s disease harmine acetylcholinesterase monoamine oxidase amyloid peptide (Aβ)
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2025.1545908/full