Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping

Abstract The G protein-coupled chemokine receptor CCR9 plays a major role in inflammatory bowel disease and is implicated in cancer. Despite its therapeutic relevance, the mechanism by which CCR9 is activated by its endogenous chemokine CCL25 remains poorly understood. Here, we combine structural mo...

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出版年:	Nature Communications
主要な著者:	Inês De Magalhaes Pinheiro, John R. D. Dawson, Nicolas Calo, Marianne Paolini-Bertrand, Kalyana Bharati Akondi, Gavin Tan, Tracy M. Handel, Irina Kufareva, Oliver Hartley
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2025-08-01
オンライン･アクセス:	https://doi.org/10.1038/s41467-025-62321-9