AIM2 Co-immunization with VP1 Is Associated with Increased Memory CD8 T Cells and Mounts Long Lasting Protection against Coxsackievirus B3 Challenge

The recurrent Coxsackievirus B3 (CVB3) infection is the most important cause of intractable myocarditis which often leads to chronic myocarditis and even dilated cardiomyopathy. Therefore, enhanced DNA vaccines capable of memory CD8 T cells are essential for long-lasting immunological protection aga...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Liang Yin, Dafei Chai, Yan Yue, Chunsheng Dong, Sidong Xiong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-06-01
Subjects:	Coxsackievirus B3 viral myocarditis DNA vaccine adjuvant AIM2 memory CD8 T cells
Online Access:	http://journal.frontiersin.org/article/10.3389/fcimb.2017.00247/full