Implications of BRAF V600E mutation in gliomas: Molecular considerations, prognostic value and treatment evolution

Gliomas are molecularly heterogeneous brain tumors responsible for the most years of life lost by any cancer. High-grade gliomas have a poor prognosis and despite multimodal treatment including surgery, radiotherapy, and chemotherapy, exhibit a high recurrence rate. There is a need for new therapeut...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Vincenzo Di Nunno, Lidia Gatto, Alicia Tosoni, Stefania Bartolini, Enrico Franceschi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	BRAF glioma glioblastoma dabrafenib trametinib vemurafenib
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1067252/full