Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction

Backgroud: Myocardial fibrosis results in myocardial remodelling and dysfunction. Celastrol, a traditional oriental medicine, has been suggested to have cardioprotective effects. However, its underlying mechanism is unknown. This study investigated the ability of celastrol to prevent cardiac fibrosi...

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Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	Mian Cheng, Gang Wu, Yue Song, Lin Wang, Ling Tu, Lizhi Zhang, Cuntai Zhang
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
Subjects:	Micro RNA-21 Celastrol ERK Myocardial fibrosis
Online Access:	http://www.karger.com/Article/FullText/445554