Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development

This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. The selective disruption of protein–protein interactions remains challenging, as the interacting surfaces are relatively large and flat. However, highly constrained p...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Binu Jacob, Alicia Vogelaar, Enrique Cadenas, Julio A. Camarero
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Subjects:	cyclotides drug design backbone cyclized polypeptides protein–protein interactions Cys-rich peptides
Online Access:	https://www.mdpi.com/1420-3049/27/19/6430