Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell

Abstract Background The chimeric antigen receptor-expressing T (CAR-T) cells for cancer immunotherapy have obtained considerable clinical importance. CAR T cells need an optimized intracellular signaling domain to get appropriately activated and also for the proper antigen recognition, the length an...

Full description

Bibliographic Details

Published in:	BMC Biotechnology
Main Authors:	Fatemeh Hajari Taheri, Mahmoud Hassani, Zahra Sharifzadeh, Mahdi Behdani, Shahryar Abdoli, Mahtab Sayadi, Kowsar Bagherzadeh, Arash Arashkia, Mohsen Abolhassani
Format:	Article
Language:	English
Published:	BMC 2024-01-01
Subjects:	Chimeric antigen receptor (CAR) IgG1 CH2-CH3 Hinge Spacer domain VEGFR2
Online Access:	https://doi.org/10.1186/s12896-023-00827-0