miR-210 locus deletion disrupts cellular homeostasis: an integrated genetic study

Abstract MiR-210 is widely recognized as the quintessential hypoxia-responsive miRNA and is thought to fine-tune various facets of cellular homeostasis. We hereby present an integrative appraisal of the phenotypic and molecular repercussions of disrupting the corresponding locus in human and mouse c...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Mihai Bogdan Preda, Evelyn Gabriela Nastase-Rusu, Carmen Alexandra Neculachi, Xiaoling Zhong, Christine Voellenkle, Nathalie M. Mazure, Ovidiu Balacescu, Cristina Ivan, Xiao-Wei Zheng, Mihaela Gherghiceanu, Kevin Lebrigand, Maya Simionescu, Fabio Martelli, Bernard Mari, Sergiu-Bogdan Catrina, Alexandrina Burlacu, Mircea Ivan
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	Gene editing technologies Genomic neighborhood Hypoxia miR-210 Targets
Online Access:	https://doi.org/10.1038/s41598-025-07572-8