Homocysteine promotes cardiomyocyte hypertrophy through inhibiting β-catenin/ FUNDC1 mediated mitophagy

Abstract Homocysteine can cause damage to cardiomyocytes. However, Mitophagy is essential for preserving homeostasis in cardiomyocytes. So, we focused on investigating the impact of homocysteine on cardiomyocyte mitophagy and cardiac hypertrophy through the β-catenin/FUNDC1 pathway. Mice were admini...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Yanping Lei, Hengjing Hu, Huifang Tang, Hui Sun, Rui Liu, Yue Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Subjects:
Homocysteine
β-catenin
FUNDC1
Mitophagy
Cardiomyocyte hypertrophy
Online Access:https://doi.org/10.1038/s41598-025-06772-6

Internet

https://doi.org/10.1038/s41598-025-06772-6

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