Novel selective glucocorticoid receptor modulator GRM-01 demonstrates dissociation of anti-inflammatory effects from adverse effects on glucose and bone metabolism

IntroductionThe development of selective GR agonist and modulators (SEGRAMs) aimed to minimize the adverse effects of chronic glucocorticoid treatment (e.g., hyperglycemia and osteoporosis) by separating the transactivation and transrepression activities of the glucocorticoid receptor (GR). Herein w...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Florian Jakob, Stephanie Hennen, Michael Gautrois, Feras Khalil, Andrew Lockhart
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	anti-inflammatory agents glucocorticoids glucocorticoid receptor modulator gluconeogenesis inflammation osteoblasts
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1542351/full