USP7 protects TFEB from proteasome-mediated degradation
Summary: The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy. We identify a distinct nuclear interactome of TFEB, with ubiquitin-specific protease 7 (USP7) emerging as a key post-translational modulator of TFEB. Genetic depletion and inhibition of USP7 reve...
| Published in: | Cell Reports |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-11-01
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| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724012233 |