Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection

Abstract Enterococcus faecalis is responsible for numerous serious infections, and treatment options often include ampicillin combined with an aminoglycoside or dual beta-lactam therapy with ampicillin and a third-generation cephalosporin. The mechanism of dual beta-lactam therapy relies on the satu...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Simone Giuliano, Jacopo Angelini, Floriana Campanile, Paola Conti, Sarah Flammini, Alberto Pagotto, Francesco Sbrana, Luca Martini, Denise D’Elia, Mohd H. Abdul-Aziz, Menino O. Cotta, Jason A. Roberts, Robert A. Bonomo, Carlo Tascini
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-01-01
Subjects:	Ampicillin Ceftobiprole Enterococcus faecalis Infective endocarditis Synergism Therapeutic drug monitoring
Online Access:	https://doi.org/10.1038/s41598-025-87512-8