A Host Factor GPNMB Restricts Porcine Circovirus Type 2 (PCV2) Replication and Interacts With PCV2 ORF5 Protein

Porcine circovirus type 2 (PCV2) is the infectious agent of postweaning multisystemic wasting syndrome (PMWS). The recently discovered open reading frame 5 (ORF5) in PCV2 genome encodes a non-structural protein. Previous study revealed that ORF5 protein inhibits cell proliferation and may interact w...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Kangkang Guo, Lei Xu, Mengmeng Wu, Yufeng Hou, Yanfen Jiang, Jiangman Lv, Panpan Xu, Zhixin Fan, Ruiqi Zhang, Fushan Xing, Yanming Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-01-01
Subjects:	porcine circovirus type 2 (PCV2) transmembrane glycoprotein NMB (GPNMB) open reading frame 5 (ORF5) Cyclin A virus-host interaction
Online Access:	https://www.frontiersin.org/article/10.3389/fmicb.2018.03295/full