Regioselective Pd-Catalyzed Hydroalkynylation of Allenyl-Containing α-Amino Acid Derivatives with Terminal Alkynes

An efficient access to the novel representatives of α,α-disubstituted α-amino acids with 1,3-enyne unit located at their side chain has been elaborated. The method is based on Pd(II)-catalyzed hydroalkynylation of α-allenyl-α-dimethylamino esters with terminal acetylenes. The developed strategy is t...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Alexandra S. Bubnova, Daria V. Vorobyeva, Ivan A. Godovikov, Anna N. Philippova, Pavel S. Gribanov, Evgenia P. Antoshkina, Sergey N. Osipov
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	1,3-enynes allenes alkynes hydroalkynylation catalysis
Online Access:	https://www.mdpi.com/1420-3049/30/17/3623