Regioselective Pd-Catalyzed Hydroalkynylation of Allenyl-Containing α-Amino Acid Derivatives with Terminal Alkynes

An efficient access to the novel representatives of α,α-disubstituted α-amino acids with 1,3-enyne unit located at their side chain has been elaborated. The method is based on Pd(II)-catalyzed hydroalkynylation of α-allenyl-α-dimethylamino esters with terminal acetylenes. The developed strategy is t...

詳細記述

書誌詳細
出版年:Molecules
主要な著者: Alexandra S. Bubnova, Daria V. Vorobyeva, Ivan A. Godovikov, Anna N. Philippova, Pavel S. Gribanov, Evgenia P. Antoshkina, Sergey N. Osipov
フォーマット: 論文
言語:英語
出版事項: MDPI AG 2025-09-01
主題:
1,3-enynes
allenes
alkynes
hydroalkynylation
catalysis
オンライン･アクセス:https://www.mdpi.com/1420-3049/30/17/3623
その他の書誌記述
要約:An efficient access to the novel representatives of α,α-disubstituted α-amino acids with 1,3-enyne unit located at their side chain has been elaborated. The method is based on Pd(II)-catalyzed hydroalkynylation of α-allenyl-α-dimethylamino esters with terminal acetylenes. The developed strategy is the first example of the metal-catalyzed allene-alkyne coupling to provide a convenient route to new unsaturated α-amino acid derivatives in good yields and high selectivity.
ISSN:1420-3049

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