Combining RNA Interference and RIG-I Activation to Inhibit Hepatitis E Virus Replication

Hepatitis E virus (HEV) poses a significant global health threat, with an estimated 20 million infections occurring annually. Despite being a self-limiting illness, in most cases, HEV infection can lead to severe outcomes, particularly in pregnant women and individuals with pre-existing liver diseas...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Mathias Ziersch, Dominik Harms, Lena Neumair, Anke Kurreck, Reimar Johne, C.-Thomas Bock, Jens Kurreck
Format:	Article
Language:	English
Published:	MDPI AG 2024-08-01
Subjects:	HEV siRNA RNAi therapy RIG-I RNA 5′triphosphate
Online Access:	https://www.mdpi.com/1999-4915/16/9/1378